The positive and negative predictive values of serum dog-specific IgG were also higher than those of serum dog-specific IgE (100.0% vs.
IGG AIRBORNE KINGDOM SKIN
The sensitivity and specificity of serum dog-specific IgG against skin prick test results were both higher than those of serum dog-specific IgE (50.0% vs. Positivity for serum dog-specific IgG antibodies was significantly higher in the perennial group (30.8%) than in the control or seasonal group (0.0% and 0.0%, p=0.0116). A positive result for serum dog-specific IgE antibodies was significantly higher in the seasonal and perennial groups (30.8 and 38.5%) than in the control group (0.0%, p=0.0482) (Table 1). There were significant differences in the total tear IgE positive rate among the control, seasonal, and perennial groups (0.0%, 100.0%, and 100.0%, p<0.0001) (Table 1). Comparison Of Each Test Among The Control, Seasonal, And Perennial Groups
IGG AIRBORNE KINGDOM SOFTWARE
SAS System software was used for all analyses (SAS Institute Inc., Cary, North Carolina, USA).ģ.1. P values of less than 0.05 were regarded as significant. The probable associated factors for the total score and the skin prick test result were analyzed using the multivariate logistic regression analysis. The differences between the two correlations were analyzed with Fisher’s Z transformation. Correlations were evaluated by Pearson’s correlation coefficients. Diagnostic accuracy was evaluated by means of positive and negative predictive values, specificity, and sensitivity. Semiquantitative analysis was performed by the two-tailed Mann-Whitney U test for two groups and Kruskal-Wallis one-way analysis of variance by ranks for three groups. The chi-square test of independence or Fisher’s exact probability test was used for the analysis of frequencies. The two-tailed unpaired Student’s t-test, one-way analysis of variance, and Scheffe’s multiple comparison test were performed for the comparison among groups. In this study, the clinical impact of dog-specific IgG antibodies against allergic conjunctivitis has been investigated.
However, it has not been examined whether dog allergens are associated with allergic conjunctivitis.
Thus, more people own dogs than cats in Japan, and dog allergens are a major cause of indoor allergen-induced allergic diseases along with cat allergens. Īccording to the Japan Pet Food Association, there were approximately 10.9 million dogs and 9.7 million cats as pets in Japan in 2013, with at least one dog in 15.8% and at least one cat in 10.1% of Japanese households. It has been previously suggested that specific IgG antibodies may be involved in perennial allergic conjunctivitis by measuring the serum level of cat-specific IgE antibodies. IgE level increases in seasonal allergic conjunctivitis. Recently, a screening test using IgG measurement has been used to diagnose allergic diseases, but measuring the serum IgG level for the assessment of allergic diseases has not yet gained popularity.Īllergic conjunctivitis is classified as seasonal, perennial, or atopic conjunctivitis.
It has been also reported IgG increased in patients with wheezing in childhood or with food allergy. Specific IgG antibodies to viruses or other pathogens can be detected during the acute phase of infection. IgG is involved in protection against infection by bacteria, fungi, and viruses through immobilization and opsonization of pathogens to which IgG antibodies bind. Human immunoglobulin (Ig) has five classes IgA, IgG, IgM, IgD, and IgE. Immunoglobulins are complex proteins that recognize cell surface antigens and protect the host against various pathogens as well as against malignancy.
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